Transitional Cell Carcinoma (TCC) Kidney Cancer, also known as Upper Urinary Tract Urothelial Carcinoma (UUTUC), is a rare form of cancer that affects the lining of the kidney or the ureters. The ureters are responsible for carrying urine from the kidneys to the bladder. This type of cancer often goes unnoticed at first, with individuals only experiencing symptoms once the tumor has progressed significantly.
People with early-stage UUTUC may not display any symptoms initially. However, as the tumor grows, symptoms may begin to surface. These symptoms include blood in the urine, persistent back pain, extreme fatigue, unexplained weight loss, and painful or frequent urination. It is essential to note that these symptoms can also be indicative of other underlying conditions.
Changes in the behavior of transitional cells in the renal pelvis and ureters are responsible for the development of UUTUC. Factors such as DNA damage due to personal history of bladder cancer, smoking, family history of Lynch syndrome, certain pain medications, exposure to aristolochic acid, and contact with specific dyes and chemicals increase the risk of developing TCC kidney cancer.
Healthcare professionals utilize various tests and procedures to diagnose UUTUC, including physical exams, urinalysis, ureteroscopy, urine cytology, CT or CAT scans, ultrasound scans, MRI scans, and biopsies. These diagnostic methods help determine the extent of the cancer and assist in devising an appropriate treatment plan.
Treatment options for UUTUC depend on factors such as the patient’s overall health, the stage of cancer, and the presence of other medical conditions. Options include endoscopic ablation, chemotherapy, and surgery. Surgical procedures, such as nephroureterectomy, segmental ureterectomy, and lymph node dissection, are common in treating UUTUC.
The survival rate for early-stage TCC kidney cancer can exceed 90%; however, if the cancer has metastasized or penetrated the bladder lining, the survival rate drastically decreases to 15% or lower. The aggressiveness of TCC kidney cancer is influenced by various factors, with advanced stages demonstrating higher levels of aggressiveness.
Transitional Cell Carcinoma (TCC) Kidney Cancer poses a significant threat to individuals due to its silent progression and potentially devastating consequences. Understanding the symptoms, causes, diagnosis, and treatment options associated with UUTUC is crucial in ensuring timely intervention and optimal outcomes. By raising awareness about the dangers of TCC kidney cancer, we can empower individuals to take proactive steps towards early detection and effective management of this rare form of cancer.